BDBM50435735 CHEMBL2392553

SMILES COc1cc(ccc1Nc1ncc2N(C)C(=O)C(F)(F)CN(C3CCCC3)c2n1)C(=O)NC1CCN(C)CC1

InChI Key InChIKey=DJNZZLZKAXGMMC-UHFFFAOYSA-N

Data  1 IC50  6 Kd

PDB links: 6 PDB IDs match this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50435735   

TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Takeda California

Curated by ChEMBL

LigandBDBM50435735(CHEMBL2392553)Copy SMILESCopy InChI

Affinity DataIC50:  4nMAssay Description:Inhibition of PLK1 (unknown origin) using biotin-AGAGTVPESIHSFIGDGLV as substrate by TR-FRET assayMore data for this Ligand-Target Pair

Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar

Ligand InfoPurchaseCHEMBLMCE
PC cidPC sidPDBSimilars

In DepthDetails ArticlePubMedPDB3D Structure (crystal)
Copy BDB DOI